Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum

J Ethnopharmacol. 2004 Jan;90(1):17-20. doi: 10.1016/j.jep.2003.09.006.


Fresh fruit bodies of Ganoderma lucidum were extracted with 70% ethanol at room temperature. The extract (GL) showed significant anti-angiogenic activity, which was detected using a chick embryo chorioallantoic membrane assay. GL significantly inhibited LPS-induced NO production in RAW 264.7 macrophages. These results support the anti-tumor effect of Ganoderma lucidum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / pharmacology*
  • Animals
  • Chick Embryo
  • Fruit
  • In Vitro Techniques
  • Nitric Oxide / antagonists & inhibitors*
  • Nitric Oxide / biosynthesis
  • Plant Extracts / pharmacology
  • Reishi*


  • Angiogenesis Inhibitors
  • Plant Extracts
  • Nitric Oxide