Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum

Yun Seon Song; Sun-Hyoung Kim; Jae-Hoon Sa; Changbae Jin; Chang-Jin Lim; Eun-Hee Park

doi:10.1016/j.jep.2003.09.006

Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum

J Ethnopharmacol. 2004 Jan;90(1):17-20. doi: 10.1016/j.jep.2003.09.006.

Authors

Yun Seon Song¹, Sun-Hyoung Kim, Jae-Hoon Sa, Changbae Jin, Chang-Jin Lim, Eun-Hee Park

Affiliation

¹ Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, PO Box 131, Seoul 130-650, South Korea.

PMID: 14698502
DOI: 10.1016/j.jep.2003.09.006

Abstract

Fresh fruit bodies of Ganoderma lucidum were extracted with 70% ethanol at room temperature. The extract (GL) showed significant anti-angiogenic activity, which was detected using a chick embryo chorioallantoic membrane assay. GL significantly inhibited LPS-induced NO production in RAW 264.7 macrophages. These results support the anti-tumor effect of Ganoderma lucidum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiogenesis Inhibitors / pharmacology*
Animals
Chick Embryo
Fruit
In Vitro Techniques
Nitric Oxide / antagonists & inhibitors*
Nitric Oxide / biosynthesis
Plant Extracts / pharmacology
Reishi*

Substances

Angiogenesis Inhibitors
Plant Extracts
Nitric Oxide