Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism

J Ethnopharmacol. 2004 Jan;90(1):39-43. doi: 10.1016/j.jep.2003.09.018.


The hypoglycemic and anti-diabetic effect of Rehmannia glutinosa oligosaccharide (ROS) in glucose-induced hyperglycemic and alloxan-induced diabetic rats and its mechanism was investigated in this paper. It was found that pretreatment of ROS in normal rats with 100 mg/kg for 3 days, i.p., induced a partial prevention of hyperglycemia caused by glucose (2g/kg, i.p.), while when hyperglycemia was induced in adrenalectomized (ADX) rats, the preventive effect of ROS on hyperglycemia was lost. In alloxan-induced diabetic rats, ROS (100 mg/kg for 15 days, i.p.) showed a significant decrease in blood glucose level and hepatic glucose-6-phosphatase activity with an increase in hepatic glycogen content. Furthermore, ROS raised plasma insulin level and lowered plasma corticosterone level in alloxan-induced diabetic rats. The results indicated that oligosaccharide of Rehmannia glutinosa Libosch. exerted a significant hypoglycemic effect in normal and alloxan-induced diabetic rats. The regulatory mechanism of ROS on glucose metabolism was adrenal dependent and had a close relation with the neuroendocrine system.

MeSH terms

  • Alloxan
  • Animals
  • Blood Glucose / analysis
  • Corticosterone / antagonists & inhibitors
  • Corticosterone / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Female
  • Glucose-6-Phosphatase / antagonists & inhibitors
  • Hyperglycemia / drug therapy*
  • Insulin / biosynthesis
  • Insulin / blood
  • Liver Glycogen / biosynthesis
  • Medicine, Chinese Traditional
  • Oligosaccharides / therapeutic use*
  • Phytotherapy
  • Plant Extracts / therapeutic use
  • Plant Roots
  • Rats
  • Rats, Wistar
  • Rehmannia*


  • Blood Glucose
  • Insulin
  • Liver Glycogen
  • Oligosaccharides
  • Plant Extracts
  • Alloxan
  • Glucose-6-Phosphatase
  • Corticosterone