PET measures of pre- and post-synaptic cardiac beta adrenergic function

Nucl Med Biol. 2003 Nov;30(8):795-803. doi: 10.1016/j.nucmedbio.2003.09.002.


Positron Emission Tomography was used to measure global and regional cardiac beta-adrenergic function in 19 normal subjects and 9 congestive heart failure patients. [(11)C]-meta-hydroxyephedrine was used to image norepinephrine transporter function as an indicator of pre-synaptic function and [(11)C]-CGP12177 was used to measure cell surface beta-receptor density as an indicator of post-synaptic function. Pre-synaptic, but not post-synaptic, function was significantly different between normals and CHF patients. Pre-synaptic function was well matched to post-synaptic function in the normal hearts but significantly different and poorly matched in the CHF patients studied. This imaging technique can help us understand regional sympathetic function in cardiac disease.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Autonomic Nervous System Diseases / diagnostic imaging
  • Autonomic Nervous System Diseases / metabolism
  • Female
  • Heart / diagnostic imaging
  • Heart / innervation
  • Heart Failure / diagnostic imaging*
  • Heart Failure / metabolism*
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Male
  • Middle Aged
  • Pilot Projects
  • Receptors, Adrenergic, beta / metabolism*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Synapses / diagnostic imaging*
  • Synapses / metabolism*
  • Tissue Distribution
  • Tomography, Emission-Computed / methods


  • Receptors, Adrenergic, beta