Adequacy of Early Empiric Antibiotic Treatment and Survival in Severe Sepsis: Experience From the MONARCS Trial

Clin Infect Dis. 2004 Jan 15;38(2):284-8. doi: 10.1086/379825. Epub 2003 Dec 22.

Abstract

As part of the Monoclonal Anti-TNF: A Randomized Controlled Sepsis (MONARCS) trial, which enrolled patients with suspected sepsis, we sought to determine whether adequate antibiotic therapy was associated with a decreased mortality rate. The study enrolled 2634 patients, 91% of whom received adequate antibiotic therapy. The mortality rate among patients given adequate antibiotic treatment was 33%, versus 43% among patients given inadequate treatment (P<.001). We conclude that adequate antibiotic therapy results in a significant decrease in the crude mortality rate among patients suspected of sepsis.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sepsis / drug therapy*
  • Sepsis / mortality
  • Shock, Septic / drug therapy
  • Shock, Septic / mortality
  • Survival Analysis

Substances

  • Anti-Bacterial Agents