Gene regulatory factors in pancreatic development

Dev Dyn. 2004 Jan;229(1):176-200. doi: 10.1002/dvdy.10460.


The intensity of research on pancreatic development has increased markedly in the past 5 years, primarily for two reasons: we now know that the insulin-producing beta-cells normally arise from an endodermally derived, pancreas-specified precursor cell, and successful transplants of islet cells have been performed, relieving patients with type I diabetes of symptoms for extended periods after transplantation. Combining in vitro beta-cell formation from a pancreatic biopsy of a diabetic patient or from other stem-cell sources followed by endocrine cell transplantation may be the most beneficial route for a future diabetes therapy. However, to achieve this, a thorough understanding of the genetic components regulating the development of beta-cells is required. The following review discusses our current understanding of the transcription factor networks necessary for pancreatic development and how several genetic interactions coming into play at the earliest stages of endodermal development gradually help to build the pancreatic organ. Developmental Dynamics 229:176-200, 2004.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Endoderm / cytology
  • Gene Expression Regulation, Developmental*
  • Genes, Homeobox
  • Humans
  • In Vitro Techniques
  • Islets of Langerhans / cytology
  • Islets of Langerhans / embryology
  • Islets of Langerhans / physiology
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology
  • Mice
  • Models, Biological
  • Morphogenesis
  • Pancreas / cytology
  • Pancreas / embryology*
  • Pancreas / physiology
  • Rats
  • Receptors, Notch
  • Signal Transduction
  • Stem Cells / cytology


  • Membrane Proteins
  • Receptors, Notch