Aminopeptidase A, generating one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, plays a key role in central control of blood pressure

Proc West Pharmacol Soc. 2003;46:39-44.
No abstract available

MeSH terms

  • Angiotensin II / physiology
  • Angiotensin III / biosynthesis
  • Angiotensin III / physiology*
  • Animals
  • Binding Sites
  • Blood Pressure / physiology*
  • Brain Chemistry / physiology
  • CD13 Antigens / antagonists & inhibitors
  • Crystallography, X-Ray
  • Drug Design
  • Enzyme Inhibitors / pharmacology
  • Glutamyl Aminopeptidase / chemistry
  • Glutamyl Aminopeptidase / genetics
  • Glutamyl Aminopeptidase / physiology*
  • Humans
  • Male
  • Methionine / analogs & derivatives*
  • Methionine / pharmacology
  • Mice
  • Models, Molecular
  • Mutagenesis, Site-Directed
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Renin-Angiotensin System / physiology*
  • Sulfhydryl Compounds / pharmacology
  • Sulfonic Acids / pharmacology

Substances

  • 2-amino-4-methylsulfonyl butane thiol
  • EC 33
  • Enzyme Inhibitors
  • Sulfhydryl Compounds
  • Sulfonic Acids
  • Angiotensin II
  • Angiotensin III
  • EC 27
  • Methionine
  • CD13 Antigens
  • Glutamyl Aminopeptidase