Stem cells and nervous tissue repair: from in vitro to in vivo

Prog Brain Res. 2004;146:75-91. doi: 10.1016/s0079-6123(03)46005-6.

Abstract

Recent development in stem cell biology has indicated a new possible approach for the treatment of neurological diseases. However, in spite of tremendous hope generated, we are still on the way to understand if the use of stem cells to repair mature brain and spinal cord is a reliable possibility. In particular, we know very little on the in situ regulation of adult neural stem, and this also negatively impact on cell transplant possibilities. In this chapter we will discuss issues concerning the role and function of stem cells in neurological diseases, with regard to the impact of features of degenerating neurons and glial cells on in situ stem cells. Stem cell location and biology in the adult brain, brain host reaction to transplantation, neural stem cell reaction to experimental injuries and possibilities for exogenous regulation are the main topics discussed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2',3'-Cyclic-Nucleotide Phosphodiesterases / metabolism
  • Animals
  • Bisbenzimidazole / metabolism
  • Blotting, Western / methods
  • Brain / cytology
  • Brain Diseases / complications
  • Brain Diseases / therapy*
  • Cell Differentiation
  • Cell Division / physiology
  • Cells, Cultured
  • Cerebral Ventricle Neoplasms / metabolism
  • Encephalomyelitis, Autoimmune, Experimental / metabolism
  • Epidermal Growth Factor / administration & dosage
  • Epidermal Growth Factor / metabolism
  • Fluorescent Antibody Technique / methods
  • Glial Fibrillary Acidic Protein / metabolism
  • In Vitro Techniques
  • Injections, Intraventricular / mortality
  • Intermediate Filament Proteins / metabolism
  • Male
  • Microscopy, Confocal / methods
  • Neoplasms / metabolism
  • Nerve Degeneration / etiology
  • Nerve Degeneration / therapy*
  • Nerve Growth Factor / metabolism
  • Nerve Tissue Proteins*
  • Nestin
  • Neural Cell Adhesion Molecule L1 / metabolism
  • Neuroglia / metabolism
  • Neurons / metabolism
  • Rats
  • Sialic Acids / metabolism
  • Stem Cell Transplantation / methods
  • Stem Cells / physiology*
  • Wound Healing*

Substances

  • Glial Fibrillary Acidic Protein
  • Intermediate Filament Proteins
  • Nerve Tissue Proteins
  • Nes protein, rat
  • Nestin
  • Neural Cell Adhesion Molecule L1
  • Sialic Acids
  • polysialyl neural cell adhesion molecule
  • Epidermal Growth Factor
  • Nerve Growth Factor
  • 2',3'-Cyclic-Nucleotide Phosphodiesterases
  • Bisbenzimidazole