Plasma amino acid concentrations in the overtraining syndrome: possible effects on the immune system

Med Sci Sports Exerc. 1992 Dec;24(12):1353-8.


Overtraining and long-term exercise are associated with an impairment of immune function. We provide evidence in support of the hypothesis that the supply of glutamine, a key fuel for cells of the immune system, is impaired in these conditions and that this may contribute to immunosuppression. Plasma glutamine concentration was decreased in overtrained athletes and after long-term exercise (marathon race) and was increased after short-term, high intensity exercise (sprinting). Branched chain amino acid supplementation during long-term exercise was shown to prevent this decrease in the plasma glutamine level. Overtraining was without effect on the rate of T-lymphocyte proliferation in vitro or on the plasma levels of interleukin-1 and -6, suggesting that immune function is not impaired in this condition. Given the proposed importance of glutamine for cells of the immune system, it is concluded that the decrease in plasma glutamine concentration in overtraining and following long-term exercise, and not an intrinsic defect in T lymphocyte function, may contribute to the immune deficiency reported in these conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alanine / blood
  • Amino Acids / blood*
  • Amino Acids, Branched-Chain / blood
  • Amino Acids, Branched-Chain / pharmacology
  • Exercise / physiology*
  • Glutamates / blood
  • Glutamine / blood
  • Humans
  • Immunosuppression Therapy*
  • Lymphocyte Activation
  • T-Lymphocytes / immunology
  • Time Factors


  • Amino Acids
  • Amino Acids, Branched-Chain
  • Glutamates
  • Glutamine
  • Alanine