Summing up ligand binding interactions

Chem Biol. 2003 Dec;10(12):1143-4. doi: 10.1016/j.chembiol.2003.12.006.


Artificial molecular recognition systems show negligible positive binding cooperativity compared to biological systems, possibly because rigid ligands cannot accommodate numerous partly bound states that comprise overall ligand binding affinity. This directly correlates with the phenomenon of enthalpy-entropy compensation.

Publication types

  • Comment

MeSH terms

  • Allosteric Regulation
  • Ligands*
  • Thermodynamics


  • Ligands