Fixed dilated pupil (Urrets-Zavalia syndrome) in corneal dystrophies

Cornea. 2004 Jan;23(1):81-3. doi: 10.1097/00003226-200401000-00014.


Purpose: To report fixed dilated pupil following penetrating keratoplasty for corneal dystrophies.

Methods: Retrospective chart analysis of subjects who underwent penetrating keratoplasty for corneal dystrophies between 1998 and 2002 at our institute.

Results: Three of the subjects with fixed dilated pupils after penetrating keratoplasty had Macular corneal dystrophy and one subject had Fuchs Endothelial dystrophy. Fixed dilated pupils were noticed in the immediate postoperative period. None of the subjects had evidence for glaucoma either pre- or postoperatively. The follow up period ranged from 5 to 18 months.

Conclusions: Fixed dilated pupil (Urrets-Zavalia syndrome) can occur after penetrating keratoplasty for corneal dystrophies and may not be limited to eyes with keratoconus as previously reported.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Corneal Dystrophies, Hereditary / surgery*
  • Female
  • Fuchs' Endothelial Dystrophy / surgery*
  • Humans
  • Keratoplasty, Penetrating / adverse effects*
  • Male
  • Middle Aged
  • Pupil Disorders / etiology*
  • Pupil Disorders / pathology
  • Syndrome