VEGF: A Critical Player in Neurodegeneration

J Clin Invest. 2004 Jan;113(1):14-8. doi: 10.1172/JCI20682.

Abstract

VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor also has direct effects on neural cells. Abnormal regulation of VEGF expression has now been implicated in several neurodegenerative disorders, including motoneuron degeneration. This has stimulated an increasing interest in assessing the therapeutic potential of VEGF as a neuroprotective agent for such neurodegenerative disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Models, Biological
  • Nerve Degeneration / physiopathology*
  • Neurodegenerative Diseases / genetics
  • Vascular Endothelial Growth Factor A / genetics
  • Vascular Endothelial Growth Factor A / physiology*

Substances

  • Vascular Endothelial Growth Factor A