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, 10 (1), 29-30

Escape of Malaria Parasites From Host Immunity Requires CD4+ CD25+ Regulatory T Cells

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Escape of Malaria Parasites From Host Immunity Requires CD4+ CD25+ Regulatory T Cells

Hajime Hisaeda et al. Nat Med.

Abstract

Infection with malaria parasites frequently induces total immune suppression, which makes it difficult for the host to maintain long-lasting immunity. Here we show that depletion of CD4(+)CD25(+) regulatory T cells (T(reg)) protects mice from death when infected with a lethal strain of Plasmodium yoelii, and that this protection is associated with an increased T-cell responsiveness against parasite-derived antigens. These results suggest that activation of T(reg) cells contributes to immune suppression during malaria infection, and helps malaria parasites to escape from host immune responses.

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