Escape of malaria parasites from host immunity requires CD4+ CD25+ regulatory T cells

Nat Med. 2004 Jan;10(1):29-30. doi: 10.1038/nm975. Epub 2003 Dec 21.


Infection with malaria parasites frequently induces total immune suppression, which makes it difficult for the host to maintain long-lasting immunity. Here we show that depletion of CD4(+)CD25(+) regulatory T cells (T(reg)) protects mice from death when infected with a lethal strain of Plasmodium yoelii, and that this protection is associated with an increased T-cell responsiveness against parasite-derived antigens. These results suggest that activation of T(reg) cells contributes to immune suppression during malaria infection, and helps malaria parasites to escape from host immune responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD4 Antigens / immunology*
  • Malaria / immunology*
  • Malaria / parasitology
  • Mice
  • Mice, Inbred BALB C
  • Plasmodium yoelii / immunology*
  • Receptors, Interleukin-2 / immunology*
  • T-Lymphocytes / immunology*


  • CD4 Antigens
  • Receptors, Interleukin-2