Inhibitory effects of hyssop (Hyssopus officinalis) extracts on intestinal alpha-glucosidase activity and postprandial hyperglycemia

J Nutr Sci Vitaminol (Tokyo). 2003 Oct;49(5):346-9. doi: 10.3177/jnsv.49.346.

Abstract

It has been known that Hyssopus officinalis (hyssop) is a herb that grows in the wild and is a source of natural antioxidants. We previously reported that a-glucosidase inhibitors, (2S, 3S)1-O-beta-D-6'-O-cinnamoylglucopyranosyl-3-(3", 5"-dimethoxy-4"-hydroxyphenyl)-1,2,3-propanetriol and (2S, 3S)1-O-beta-D-glucopranosyl-3-(3", 5"-dimethoxy-4"-hydroxyphenyl)-1,2,3-propanetriol, from the dry leaves of hyssop, were isolated. This study examined the alpha-glucosidase inhibitory effects of hyssop extracts on intestinal carbohydrate absorption in rat everted gut sac and carbohydrate-loaded hyperglycemia in mice. In the everted gut sac experiment, 10 mM sucrose- and 5 mM maltose-treated increases in glucose concentration in the serosal compartment were inhibited in the presence of 0.5 and 1.0 mg/ mL hyssop extracts, although a 10 mM glucose-induced increase in serosal glucose was not inhibited by the extracts. Additionally, hyperglycemia in sucrose- and maltose-loaded mice was significantly suppressed at an early stage, within 30 to 60 min by oral pre-administration of 300 and 100 mg/kg hyssop extracts, respectively. These findings suggest that hyssop extracts inhibited the digestion of complex carbohydrates, but not that of absorbable monosaccharide, and might be a useful supplemental food for hyperglycemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbohydrate Metabolism
  • Enzyme Inhibitors / pharmacology*
  • Food*
  • Glucose / analysis
  • Glucose / pharmacology
  • Glycoside Hydrolase Inhibitors*
  • Hyperglycemia / prevention & control*
  • Intestinal Absorption / drug effects
  • Intestines / enzymology*
  • Lamiaceae / chemistry*
  • Male
  • Maltose / administration & dosage
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Wistar
  • Sucrose / administration & dosage
  • alpha-Glucosidases / metabolism

Substances

  • Enzyme Inhibitors
  • Glycoside Hydrolase Inhibitors
  • Plant Extracts
  • Sucrose
  • Maltose
  • alpha-Glucosidases
  • Glucose