Acute stress-induced changes in hippocampal/prefrontal circuits in rats: effects of antidepressants

Cereb Cortex. 2004 Feb;14(2):224-9. doi: 10.1093/cercor/bhg122.


Acute stress inhibits long-term potentiation (LTP) at synapses from the hippocampus to prefrontal cortex in the rat, a model of the dysfunction in the anterior cingulate/orbitofrontal cortices which has been observed in human depression. We demonstrate that the antidepressants tianeptine and, to a lesser extent, fluoxetine, are able to reverse the impairment in LTP, a measure of frontal synaptic plasticity, caused by stress on an elevated platform. LTP was induced by stimulation of hippocampal outflow. Beneficial effects on neuronal plasticity, defined as a reversal of the effects of stress in this paradigm, can be considered as a new animal model for the impact of stress on hippocampal/frontal circuits, a key target in psychiatric diseases.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Animals
  • Fluoxetine / administration & dosage*
  • Fluoxetine / therapeutic use
  • Hippocampus / drug effects*
  • Hippocampus / physiology
  • Injections, Intraperitoneal
  • Long-Term Potentiation / drug effects*
  • Long-Term Potentiation / physiology
  • Male
  • Neural Inhibition / drug effects
  • Neural Inhibition / physiology
  • Neural Pathways / drug effects
  • Neural Pathways / physiology
  • Prefrontal Cortex / drug effects*
  • Prefrontal Cortex / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Stress, Physiological / drug therapy
  • Stress, Physiological / physiopathology*
  • Thiazepines / administration & dosage*
  • Thiazepines / therapeutic use


  • Thiazepines
  • Fluoxetine
  • tianeptine