Targeting cyclooxygenase-2 in human neoplasia: rationale and promise

Cancer Cell. 2003 Dec;4(6):431-6. doi: 10.1016/s1535-6108(03)00310-6.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Antineoplastic Agents / pharmacology*
  • Arachidonic Acid / metabolism
  • Celecoxib
  • Cyclooxygenase 2
  • Enzyme Inhibitors / pharmacology
  • Gene Expression Regulation, Neoplastic / physiology
  • Humans
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / metabolism*
  • Membrane Proteins
  • Models, Molecular
  • Neoplasms / drug therapy*
  • Neoplasms / enzymology
  • Prostaglandin-Endoperoxide Synthases / metabolism*
  • Prostaglandins / metabolism
  • Pyrazoles
  • Receptors, Prostaglandin / metabolism
  • Signal Transduction
  • Sulfonamides / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Isoenzymes
  • Membrane Proteins
  • Prostaglandins
  • Pyrazoles
  • Receptors, Prostaglandin
  • Sulfonamides
  • Arachidonic Acid
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases
  • Celecoxib