Linkage of the locus for canine dewclaw to chromosome 16

Genomics. 2004 Feb;83(2):216-24. doi: 10.1016/s0888-7543(03)00234-9.


The canine species, including wolf and jackal, have four digits on the hind limb. It was thought that an extra first digit on the hind limb, named dewclaw, was a hereditary defect. For genetically related canine pedigrees with 73 members with dewclaws, we carried out a genome-wide scan for linkage with microsatellites. With an assumption of autosomal dominant mode of inheritance, significant linkages were detected for the markers on canine chromosome 16. The maximum two-point lod score of 20.76 was obtained for the REN85M08/REN85N14 markers at a recombination fraction of 0.00. For efficient analysis of linkage, a revised order of the chromosomal markers was established by assigning all the existing markers from the previous linkage and radiation hybrid maps. A chromosome-wide haplotype analysis revealed the location of the dewclaw locus within a few centimorgan intervals delimited by the UCMCF12 and CXX876 markers. Canine chromosome 16 is known to have syntenic relationships with human chromosomes 4q, 7q, and 8p.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Mapping*
  • Chromosomes*
  • Congenital Abnormalities / genetics
  • Dogs / genetics*
  • Foot Bones / abnormalities*
  • Genetic Linkage*
  • Genetic Markers
  • Haplotypes
  • Lod Score
  • Pedigree
  • Recombination, Genetic


  • Genetic Markers