Target-selected mutagenesis of the rat

Genomics. 2004 Feb;83(2):332-4. doi: 10.1016/j.ygeno.2003.08.010.


The rat is one of the most extensively studied model organisms, and with its genome being sequenced, tools to manipulate gene function in vivo have become increasingly important. We here report proof of principle for target-selected mutagenesis as a reverse genetic or knockout approach for the rat.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA Mutational Analysis
  • Ethylnitrosourea
  • Fertility / genetics
  • Follicle Stimulating Hormone / genetics
  • Germ-Line Mutation
  • Mutagenesis* / drug effects
  • Mutagens
  • Rats
  • Rats, Mutant Strains
  • Rats, Wistar


  • Mutagens
  • Follicle Stimulating Hormone
  • Ethylnitrosourea