Anti-ulcer activity and mode of action of the polysaccharide fraction from the leaves of Panax ginseng

Planta Med. 1992 Oct;58(5):432-5. doi: 10.1055/s-2006-961507.


The effects of a weakly acidic polysaccharide fraction, GL-4, from the leaves of Panax ginseng C. A. Meyer on various experimental gastric ulcer models in mice and rats have been studied. Oral administration of GL-4 at doses of 50 to 200 mg/kg inhibited the formation of the gastric lesions induced by necrotizing agents such as HCl/ethanol and ethanol in a dose-dependent manner. This protective effect was observed not only upon oral but also upon subcutaneous administration of GL-4 (50-100 mg/kg). GL-4 also inhibited the formation of gastric ulcers which were induced by water immersion stress, indomethacin, or pylorus-ligation. The contents of prostaglandin E2 in the gastric juice from rats were not influenced by oral administration of GL-4. The protective action of GL-4 against HCl/ethanol-induced gastric lesions was not abolished by pretreatment with indomethacin. When GL-4 (100 mg/kg, p.o.) was administered into pylorus-ligated rats, both gastric acidity and pepsin activity in the gastric juice decreased significantly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Ulcer Agents / isolation & purification
  • Anti-Ulcer Agents / pharmacology*
  • Dinoprostone / metabolism
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / metabolism
  • Male
  • Mice
  • Mice, Inbred ICR
  • Panax / chemistry*
  • Plants, Medicinal*
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Rats
  • Rats, Wistar


  • Anti-Ulcer Agents
  • Polysaccharides
  • Dinoprostone