Thalamic paraventricular nucleus lesions facilitate central amygdala neuronal responses to acute psychological stress

Brain Res. 2004 Feb 6;997(2):234-7. doi: 10.1016/j.brainres.2003.10.054.


The thalamic paraventricular nucleus (PVT) is activated by stress and projects to forebrain structures directly implicated in processing stress-related information. Accordingly, it seems likely the PVT plays an important role in modulating stress responses. We examined effects of excitotoxic PVT lesions on forebrain Fos expression patterns normally elicited by an acute psychological stressor. PVT lesions significantly increased stress-induced Fos in a key stress-processing region, the central amygdala.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Air
  • Amygdala / physiopathology*
  • Animals
  • Ibotenic Acid / administration & dosage
  • Male
  • Midline Thalamic Nuclei / physiopathology*
  • Neurons / metabolism*
  • Proto-Oncogene Proteins c-fos / biosynthesis
  • Rats
  • Rats, Wistar
  • Stress, Psychological / physiopathology*


  • Proto-Oncogene Proteins c-fos
  • Ibotenic Acid