Fine structural analyses of pancreatic acinar cell nuclei from mice fed on genetically modified soybean

Eur J Histochem. 2003;47(4):385-8.

Abstract

We carried out ultrastructural morphometrical and immunocytochemical analyses on pancreatic acinar cell nuclei from mice fed on genetically modified (GM) soybean, in order to investigate possible structural and molecular modifications of nucleoplasmic and nucleolar constituents. We found a significant lowering of nucleoplasmic and nucleolar splicing factors as well as a perichromatin granule accumulation in GM-fed mice, suggestive of reduced post-transcriptional hnRNA processing and/or nuclear export. This is in accordance to already described zymogen synthesis and processing modifications in the same animals.

Publication types

  • Letter

MeSH terms

  • Animals
  • Cell Nucleolus / genetics
  • Cell Nucleus / drug effects*
  • Cell Nucleus / ultrastructure
  • Diet
  • Female
  • Food, Genetically Modified / adverse effects*
  • Mice
  • Pancreas / drug effects*
  • Pancreas / pathology
  • Plants, Genetically Modified*
  • Pregnancy
  • RNA Splicing
  • Reproduction / drug effects*
  • Soybeans* / genetics