Dendritic Ih selectively blocks temporal summation of unsynchronized distal inputs in CA1 pyramidal neurons

J Comput Neurosci. Jan-Feb 2004;16(1):5-13. doi: 10.1023/b:jcns.0000004837.81595.b0.

Abstract

The active dendritic conductances shape the input-output properties of many principal neurons in different brain regions, and the various ways in which they regulate neuronal excitability need to be investigated to better understand their functional consequences. Using a realistic model of a hippocampal CA1 pyramidal neuron, we show a major role for the hyperpolarization-activated current, Ih, in regulating the spike probability of a neuron when independent synaptic inputs are activated with different degrees of synchronization and at different distances from the soma. The results allowed us to make the experimentally testable prediction that the Ih in these neurons is needed to reduce neuronal excitability selectively for distal unsynchronized, but not for synchronized, inputs.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Computer Simulation
  • Dendrites / drug effects
  • Dendrites / physiology*
  • Excitatory Amino Acid Agonists / pharmacology
  • Excitatory Postsynaptic Potentials / drug effects
  • Excitatory Postsynaptic Potentials / physiology
  • Hippocampus / cytology
  • Hippocampus / physiology
  • Models, Neurological*
  • N-Methylaspartate / pharmacology
  • Neural Conduction / drug effects
  • Neural Conduction / physiology*
  • Probability
  • Pyramidal Cells / drug effects
  • Pyramidal Cells / physiology*
  • Reproducibility of Results
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology
  • Time Factors
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / pharmacology

Substances

  • Excitatory Amino Acid Agonists
  • N-Methylaspartate
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid