Photodynamic therapy for chronic central serous chorioretinopathy

Retina. 2003 Dec;23(6):752-63. doi: 10.1097/00006982-200312000-00002.


Purpose: To determine whether photodynamic therapy (PDT) is effective for treatment of chronic central serous chorioretinopathy (CSC).

Methods: Sixteen eyes with chronic CSC and macular detachment documented by optical coherence tomography (OCT) received PDT guided by indocyanine green (ICG) angiography according to the parameters outlined in the TAP Study. One or more laser spots were applied to the areas of choroidal vascular hyperpermeability that corresponded to retinal pigment epithelium decompensation. Patients were observed for 6 to 12 months. Two PDT sessions 1 month apart were performed on 2 eyes. Examinations included visual acuity measurement, fundus biomicroscopy, fluorescein and ICG angiography, and OCT.

Results: Macular exudation resolved completely in 13 eyes (81%) and partially regressed in 3. Choriocapillaris hypoperfusion was shown by ICG angiography for several months at the site of PDT application. Visual acuity improved 1 to 4 lines in 11 eyes and was unchanged in 5 eyes.

Conclusions: ICG-guided PDT performed according to the parameters outlined by the TAP Study seems effective for treating chronic CSC. Further studies are needed to verify treatment safety and the time and rate of recurrences.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Choroid Diseases / diagnosis
  • Choroid Diseases / drug therapy*
  • Chronic Disease
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Humans
  • Indocyanine Green
  • Male
  • Middle Aged
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use*
  • Porphyrins / therapeutic use*
  • Retinal Detachment / diagnosis
  • Retinal Detachment / drug therapy
  • Retinal Diseases / diagnosis
  • Retinal Diseases / drug therapy*
  • Tomography, Optical Coherence
  • Treatment Outcome
  • Verteporfin
  • Visual Acuity


  • Photosensitizing Agents
  • Porphyrins
  • Verteporfin
  • Indocyanine Green