Intracameral mydriatics in phacoemulsification cataract surgery

J Cataract Refract Surg. 2003 Dec;29(12):2366-71. doi: 10.1016/s0886-3350(03)00522-4.


Purpose: To evaluate intracameral injection of mydriatics in phacoemulsification cataract surgery and compare the results with those of conventional topical mydriatics.

Setting: Department of Clinical Science/Ophthalmology, Umeå University Hospital, Umeå, Sweden.

Methods: This prospective randomized double-blind study included 60 patients who were given topical (topical group) or intracameral (intracameral group) mydriatics. The topical mydriatics comprised 3 drops of cyclopentolate 1% and phenylephrine 10% given 15 minutes apart and 150 microL intracameral lidocaine hydrochloride 1% (Xylocaine) and the intracameral mydriatics, placebo eyedrops and 150 microL intracameral cyclopentolate 0.1%, phenylephrine 1.5%, and Xylocaine 1%. The pupil size was recorded preoperatively, throughout surgery, and 1 day and 1 month postoperatively. Preoperative and postoperative corneal endothelial morphology, corneal thickness, intraocular pressure, visual acuity, aqueous cells and flare, phacoemulsification energy, duration of surgery, pulse, blood pressure, and intraoperative sensation of pain and glare were also recorded.

Results: With intracameral mydriatics, mydriasis reached 95% +/- 3% (SD) of its final value within 20 seconds. In the intracameral group, the pupils were smaller than in the topical group (mean 6.7 +/- 1.0 mm versus 7.7 +/- 1.0 mm, P<.001) but did not contract intraoperatively. The pupils in the topical group tended to contract, and the difference between groups was significant (P =.0020). The intracameral group reported less glare during the procedure (P<.001). There was no difference in endothelial cell loss, inflammatory reaction, postoperative corneal swelling, or surgical performance between the groups.

Conclusions: Intracameral mydriatics were a rapid, effective, and safe alternative to topical mydriatics in phacoemulsification. Their use can simplify preoperative routines and in certain high-risk groups, may reduce the risk for cardiovascular side effects.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Aged
  • Anterior Chamber / drug effects*
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Cell Count
  • Cyclopentolate / administration & dosage
  • Double-Blind Method
  • Drug Evaluation
  • Drug Therapy, Combination
  • Endothelium, Corneal / drug effects
  • Endothelium, Corneal / pathology
  • Humans
  • Injections
  • Intraocular Pressure / drug effects
  • Intraocular Pressure / physiology
  • Lens Implantation, Intraocular
  • Lidocaine / administration & dosage
  • Mydriatics / administration & dosage*
  • Ophthalmic Solutions / administration & dosage
  • Phacoemulsification*
  • Phenylephrine / administration & dosage
  • Prospective Studies
  • Pupil / drug effects*
  • Visual Acuity / drug effects
  • Visual Acuity / physiology


  • Mydriatics
  • Ophthalmic Solutions
  • Phenylephrine
  • Lidocaine
  • Cyclopentolate