A low noise multichannel integrated circuit for recording neuronal signals using microelectrode arrays

Biosens Bioelectron. 2004 Feb 15;19(7):749-61. doi: 10.1016/j.bios.2003.08.005.

Abstract

This paper reports on the development of a fully integrated 32-channel integrated circuit (IC) for recording neuronal signals in neurophysiological experiments using microelectrode arrays. The IC consists of 32 channels of low-noise preamplifiers and bandpass filters, and an output analog multiplexer. The continuous-time RC active filters have a typical passband of 20-2000 Hz; the low and the high cut-off frequencies can be separately controlled by external reference currents. This chip provides a satisfactory signal-to-noise ratio for neuronal signals with amplitudes greater than 50 microV. For the nominal passband setting, an equivalent input noise of 3 microV rms has been achieved. A single channel occupies 0.35 mm(2) of silicon area and dissipates 1.7 mW of power. The chip was fabricated in a 0.7 microm CMOS process.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials / physiology*
  • Amplifiers, Electronic
  • Analog-Digital Conversion
  • Animals
  • Equipment Design
  • Equipment Failure Analysis
  • Haplorhini
  • Microelectrodes*
  • Miniaturization
  • Nerve Net / physiology*
  • Neurons / physiology*
  • Reproducibility of Results
  • Retinal Ganglion Cells / physiology
  • Semiconductors
  • Sensitivity and Specificity