Comparison of the effects of isotonic and hypertonic sodium bicarbonate solutions on acidemic calves experimentally induced by ammonium chloride administration

J Vet Med Sci. 2003 Dec;65(12):1369-71. doi: 10.1292/jvms.65.1369.


The objectives of this study were to evaluate and compare the effects of intravenously (IV) administered infusion of isotonic solution (ISB) or hypertonic sodium bicarbonate solution (HSB) on acid-base equilibrium and the plasma osmolarity in acidemic calves experimentally induced by 5 M-NH(4)Cl, IV infusion (1.0 ml/kg, over 1 hr). The ISB and HSB infusion induced progressive and significant increases in their HCO(3)(-) and BE levels that persisted throughout the period of fluid administration. The plasma osmolarity in the ISB groups was significantly decreased. The plasma osmolarity in the HSB group was significantly higher than in the calves in the other groups (p<0.05). ISB solution might be safe and effective for treating and reviving conscious calves from experimentally induced metabolic acidosis.

Publication types

  • Comparative Study

MeSH terms

  • Acidosis / chemically induced
  • Acidosis / therapy
  • Acidosis / veterinary*
  • Ammonium Chloride / toxicity*
  • Animals
  • Cattle
  • Cattle Diseases / therapy*
  • Hypotonic Solutions
  • Infusions, Intravenous
  • Isotonic Solutions
  • Sodium Bicarbonate / administration & dosage*
  • Sodium Bicarbonate / therapeutic use


  • Hypotonic Solutions
  • Isotonic Solutions
  • Ammonium Chloride
  • Sodium Bicarbonate