Pharmacodynamics and dosing of aminoglycosides

Infect Dis Clin North Am. 2003 Sep;17(3):503-28, v. doi: 10.1016/s0891-5520(03)00057-6.


Aminoglycosides are concentration-dependent killing agents whose pharmacodynamic predictors of efficacy are the area-under-the-curve to minimum inhibitory concentration ratio and the peak to minimum inhibitory concentration ratio. Prospective studies have shown that these agents can be given once-daily or less frequently in most clinical settings, with equal efficacy and possible reduced toxicity. Dosages for different clinical settings have been studied and methods are available to monitor once-daily dosing.

Publication types

  • Review

MeSH terms

  • Adult
  • Aminoglycosides* / adverse effects
  • Aminoglycosides* / pharmacokinetics
  • Aminoglycosides* / pharmacology
  • Animals
  • Area Under Curve
  • Child
  • Female
  • Gram-Negative Bacterial Infections / drug therapy*
  • Half-Life
  • Hearing Loss / chemically induced
  • Humans
  • Kidney Diseases / chemically induced
  • Male
  • Tissue Distribution


  • Aminoglycosides