Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study

Fertil Steril. 2004 Jan;81(1):93-8. doi: 10.1016/j.fertnstert.2003.05.009.


Objective: To clarify a potential therapeutic role of coenzyme Q(10) (CoQ(10)) in infertile men with idiopathic asthenozoospermia.

Design: Open, uncontrolled pilot study.

Patient(s): Infertile men with idiopathic asthenozoospermia.

Intervention(s): CoQ(10) was administered orally; semen samples were collected at baseline and after 6 months of therapy. MAIN OUTCOME MEASURE (S): Semen kinetic parameters, including computer-assisted sperm data and CoQ(10) and phosphatidylcholine levels.

Result(s): CoQ(10) levels increased significantly in seminal plasma and in sperm cells after treatment. Phosphatidylcholine levels also increased. A significant increase was also found in sperm cell motility as confirmed by computer-assisted analysis. A positive dependence (using the Cramer's index of association) was evident among the relative variations, baseline and after treatment, of seminal plasma or intracellular CoQ(10) content and computer-determined kinetic parameters.

Conclusion(s): The exogenous administration of CoQ(10) may play a positive role in the treatment of asthenozoospermia. This is probably the result of its role in mitochondrial bioenergetics and its antioxidant properties.

MeSH terms

  • Adult
  • Coenzymes
  • Dietary Supplements
  • Female
  • Humans
  • Infertility, Male / drug therapy
  • Male
  • Oligospermia / drug therapy*
  • Phosphatidylcholines / metabolism
  • Pregnancy
  • Pregnancy Rate
  • Semen / drug effects*
  • Semen / metabolism
  • Sperm Count
  • Treatment Outcome
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / therapeutic use*


  • Coenzymes
  • Phosphatidylcholines
  • Ubiquinone
  • coenzyme Q10