Fracture risk associated with inhaled corticosteroid use in chronic obstructive pulmonary disease

Am J Respir Crit Care Med. 2004 Apr 1;169(7):855-9. doi: 10.1164/rccm.200307-926OC. Epub 2004 Jan 7.


Patients with chronic obstructive pulmonary disease (COPD) are frequently treated with inhaled corticosteroids (ICS). However, the impact of ICS use on fracture risk remains unclear in these patients. This nested case-control study examines the association between ICS use and nonvertebral fractures in Veterans Affairs patients with COPD. From a cohort of 40,157 patients with a COPD diagnosis between October 1, 1998 and September 30, 1999, and that used services in the preceding 12-month period but did not have a COPD diagnosis, 1,708 cases with nonvertebral fractures were identified and matched to 6,817 control patients. Patients were 94% male, and average age was 62.7 years. ICS exposure was identified through prescription records and converted to beclamethasone equivalents. In conditional logistic regression models, exposure to ICS at any time during follow-up was not associated with an increased fracture risk (adjusted odds ratio = 0.97; 95% confidence interval, 0.84-1.11). However, current high-dose ICS users (> or = 700 microg per day) had an increased risk of fractures compared with patients with no exposure (adjusted odds ratio = 1.68; 95% confidence interval, 1.10-2.57). In patients with COPD, current use of high-dose ICS was associated with an increased risk of nonvertebral fractures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Adrenal Cortex Hormones / administration & dosage
  • Adrenal Cortex Hormones / adverse effects*
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Dose-Response Relationship, Drug
  • Female
  • Fractures, Bone / chemically induced*
  • Fractures, Bone / epidemiology
  • Humans
  • Male
  • Matched-Pair Analysis
  • Middle Aged
  • Pulmonary Disease, Chronic Obstructive / drug therapy*
  • Risk
  • United States / epidemiology
  • Veterans


  • Adrenal Cortex Hormones