Fibrillary glomerulonephritis associated with essential thrombocytosis

Clin Exp Nephrol. 2003 Dec;7(4):296-300. doi: 10.1007/s10157-003-0250-2.

Abstract

A 68-year-old man with a 30-year history of essential thrombocytosis developed nephrotic syndrome. Renal biopsy showed massive deposits of Congo red-negative periodic acid Schiff (PAS)-positive substance in the mesangium and capillary wall that was positive for IgG. Electron microscopic examination revealed 10- to 20-nm fibrils in the deposits, and there was no other organ involvement; thus, we diagnosed fibrillary glomerulonephritis. This is the first report of a case of fibrillary glomerulonephritis associated with essential thrombocytosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Inflammatory Agents / therapeutic use
  • Antineoplastic Agents, Alkylating / therapeutic use
  • Bone Marrow / pathology
  • Glomerulonephritis / complications*
  • Glomerulonephritis / drug therapy
  • Glomerulonephritis / pathology*
  • Humans
  • Kidney / pathology
  • Male
  • Melphalan / therapeutic use
  • Microscopy, Electron
  • Nephrotic Syndrome / complications
  • Nephrotic Syndrome / pathology
  • Prednisolone / therapeutic use
  • Thrombocytosis / complications*
  • Thrombocytosis / drug therapy
  • Thrombocytosis / pathology*

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents, Alkylating
  • Prednisolone
  • Melphalan