Antibody-induced transplantation tolerance: the role of dominant regulation

Immunol Res. 2003;28(3):181-91. doi: 10.1385/IR:28:3:181.

Abstract

A short-treatment with nondepleting antibodies, such as those targeting CD4 or CD154 (CD40 ligand), allows long-term graft survival without the need for continuous immunosuppression. This state of immune tolerance is maintained by regulatory CD4+ T cells present within both the lymphoid tissue and the tolerated graft. The nature of such regulatory T cells, their relationship to CD4+CD25+ T cells, and their mode of action have all been the subjects of much attention recently. Here, we review recent progress on understanding the nature, specificity, and mechanisms of action of T cells mediating dominant tolerance brought about by antibody therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / administration & dosage*
  • CD4-Positive T-Lymphocytes / immunology
  • Graft Survival / immunology
  • Immune Tolerance*
  • Immunosuppression
  • Mice
  • Rats
  • Receptors, Interleukin-2 / metabolism
  • T-Lymphocyte Subsets / immunology
  • Transplantation Immunology*
  • Transplantation, Homologous

Substances

  • Antibodies, Monoclonal
  • Receptors, Interleukin-2