An oral B subunit: whole cell vaccine against cholera

Vaccine. 1992;10(13):911-4. doi: 10.1016/0264-410x(92)90324-d.


During the last decade there has been a rapid progress in the development of new, much improved vaccines against cholera. These vaccines, which are given orally to stimulate the gut mucosal immune system, are based on either a combination of purified cholera toxin B (binding) subunit and killed cholera vibrios of Inaba and Ogawa serotypes and El Tor and classical biotypes (B subunit-whole cell vaccine, B-WC) or on a live attenuated mutant strain of Vibrio cholerae producing the B subunit (CVD 103-HgR). The safety of the oral B-WC cholera vaccine and the immunogenicity and protective efficacy of this vaccine against both cholera and diarrhoea caused by enterotoxigenic Escherichia coli have been extensively documented, e.g. in a large randomized, placebo-controlled field trial in 90,000 persons living in a cholera endemic area. The potential for inexpensive large-scale manufacturing of the B-WC vaccine has recently been much facilitated by the introduction of recombinant DNA technology for production of the B subunit component. This now gives promise that this vaccine could become a useful, cost-effective tool in future strategies to control cholera both in endemic situations and in relation to acute epidemic outbreaks.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Bangladesh
  • Child
  • Child, Preschool
  • Cholera / epidemiology
  • Cholera / prevention & control*
  • Cholera Toxin / immunology*
  • Cholera Vaccines* / administration & dosage
  • Cholera Vaccines* / immunology
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Vaccination
  • Vaccines, Attenuated / immunology
  • Vaccines, Inactivated / immunology
  • Vaccines, Synthetic* / immunology
  • Vibrio cholerae / immunology


  • Cholera Vaccines
  • Vaccines, Attenuated
  • Vaccines, Inactivated
  • Vaccines, Synthetic
  • Cholera Toxin