No effect of piroxicam on achilles tendinopathy. A randomized study of 70 patients

Acta Orthop Scand. 1992 Dec;63(6):631-4. doi: 10.1080/17453679209169724.


70 consecutive adult, nonrheumatic patients with a painful achilles tendinopathy were randomized to treatment with either a nonsteroid antiinflammatory drug (piroxicam) or placebo. Both groups received adjunct treatment with a period of rest combined with stretching and strengthening exercises. 52/70 cases were engaged in various sports, notably running. All subjects were evaluated on days 3, 7, 14, and 28 with respect to pain, tenderness, swelling, ankle joint movement and muscle strength. Results were judged from residual symptoms and an overall assessment of the efficacy. No differences were seen between the groups at any time during the study. The overall result was identical with a rate of success slightly better than 50 percent which corresponds to the placebo response reported in other studies.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Achilles Tendon*
  • Adolescent
  • Adult
  • Ankle Joint / physiology
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Piroxicam / pharmacology*
  • Range of Motion, Articular / physiology
  • Tendinopathy / drug therapy*


  • Piroxicam