Hip Fracture Patients May Be Vitamin B6 Deficient. Controlled Study of Serum pyridoxal-5'-phosphate

Acta Orthop Scand. 1992 Dec;63(6):635-8. doi: 10.1080/17453679209169725.

Abstract

Deficiency of vitamin B6 in rats may result in defective bone formation, possibly due to decreased activity of the enzyme ornithine decarboxylase which requires pyridoxal-5'-phosphate (PLP) as a co-factor and is responsible for production of intracellular putrescine, a metabolic regulator. We studied 3 groups of patients (62 fit ambulant out-patients, 21 elective arthroplasty patients, and 20 hip fracture patients) and assayed their PLP status by high performance liquid chromatography. The reference range derived from the out-patients was 13-106 nmol/L. 3 of the arthroplasty group and 10 of the fracture group had serum PLP concentrations less than 13 nmol/L (P < 0.01). We conclude that PLP may be an etiologic factor in hip fracture by virtue of its role in the activity of a key regulatory protein.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Chromatography, High Pressure Liquid
  • Female
  • Hip Fractures / blood
  • Hip Fractures / etiology*
  • Humans
  • Male
  • Middle Aged
  • Pyridoxal Phosphate / blood*
  • Reference Values
  • Vitamin B 6 Deficiency / blood
  • Vitamin B 6 Deficiency / complications*

Substances

  • Pyridoxal Phosphate