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Clinical Trial
, 93 (2), 154-8

Treating to New Targets (TNT) Study: Does Lowering Low-Density Lipoprotein Cholesterol Levels Below Currently Recommended Guidelines Yield Incremental Clinical Benefit?

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Clinical Trial

Treating to New Targets (TNT) Study: Does Lowering Low-Density Lipoprotein Cholesterol Levels Below Currently Recommended Guidelines Yield Incremental Clinical Benefit?

David D Waters et al. Am J Cardiol.

Abstract

The Treating to New Targets (TNT) trial is a parallel-group study that has randomized 10,003 patients from 14 countries to double-blind treatment with either atorvastatin 10 or 80 mg. During the double-blind period, low-density lipoprotein (LDL) cholesterol levels are expected to reach approximate mean values of 100 mg/dl (2.6 mmol/L) for the low-dose atorvastatin group and 75 mg/dl (1.9 mmol/L) for the high-dose group. Randomized patients are expected to be followed for an average of 5 years. The primary end point is the time to occurrence of a major cardiovascular event, defined as coronary heart disease death, nonfatal myocardial infarction, resuscitated cardiac arrest, or stroke. The large patient numbers in the TNT study and long follow-up should ensure that there is adequate power to definitively determine if reducing LDL cholesterol levels to approximately 75 mg/dl (1.9 mmol/L) can provide additional clinical benefit.

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