Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes

J Clin Endocrinol Metab. 2004 Jan;89(1):207-12. doi: 10.1210/jc.2003-031402.

Abstract

The objective of this study was to examine relationships between impaired glucose tolerance (IGT) and body composition and insulin-related phenotypes in 150 overweight Latino children with a family history of type 2 diabetes. Glucose tolerance was assessed by an oral glucose challenge. Body composition was assessed by dual energy x-ray absorptiometry and magnetic resonance imaging. Insulin sensitivity, the acute insulin response, and the disposition index (DI), as an index of beta-cell function, were determined by an iv glucose tolerance test and compared between normal glucose-tolerant and IGT children. IGT was present in 28% of children, and was similar across obesity groups, but higher in children exposed to gestational diabetes mellitus (41% IGT). There were no significant differences in body composition, fat distribution, insulin sensitivity, or acute insulin response, but DI was significantly lower in IGT children by 16% (P < 0.02), and DI was inversely related to age. In conclusion, IGT is present in 28% of overweight Latino children with a family history of type 2 diabetes, is not influenced by obesity, is more prevalent in children exposed to gestational diabetes mellitus, and is related to poor beta-cell function, which shows signs of deterioration with age in this population.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Absorptiometry, Photon
  • Aging
  • Birth Weight
  • Blood Glucose / analysis
  • Body Composition
  • Body Constitution
  • Body Mass Index
  • Child
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes, Gestational / complications
  • Family
  • Fasting
  • Female
  • Glucose Intolerance / epidemiology*
  • Glucose Intolerance / etiology
  • Glucose Intolerance / physiopathology
  • Glucose Tolerance Test
  • Hispanic Americans*
  • Humans
  • Insulin / blood
  • Islets of Langerhans / physiopathology*
  • Male
  • Obesity / complications*
  • Obesity / physiopathology
  • Pregnancy
  • Puberty
  • Regression Analysis

Substances

  • Blood Glucose
  • Insulin