Twelve long-distance runners were evaluated by physical examination, electrocardiogram, vectorcardiogram, chest x-ray film, and echocardiogram; and the results were compared to the findings in 12 normal control subjects. The athletes showed a significantly higher frequency of gallop rhythms with a third or fourth heart sound. Electrocardiographic and vectorcardiographic abnormalities consisting of right or left ventricular hypertrophy, bradycardia, and alterations in the ST-T wave were also present in the runners. Echocardiographic examination of the athletes revealed increased wall thickness, left ventricular muscular mass, diastolic volume, and ventricular function. It is essential that the physician who examines athletes be aware of the spectrum of apparently abnormal findings in this group. Echocardiographic studies should prove useful in establishing the presence or absence of some forms of cardiac disease in athletes.