Levofloxacin treatment failure in Haemophilus influenzae pneumonia

Emerg Infect Dis. 2003 Nov;9(11):1475-8. doi: 10.3201/eid0911.030176.

Abstract

We describe the first case of failure of oral levofloxacin treatment of community-acquired pneumonia caused by Haemophilus influenzae. The strain showed cross-resistance to fluoroquinolones and carried four mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV genes.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anti-Infective Agents / therapeutic use*
  • Community-Acquired Infections / drug therapy*
  • DNA Gyrase / drug effects
  • DNA Gyrase / genetics*
  • Electrophoresis, Gel, Pulsed-Field
  • Fatal Outcome
  • Female
  • Haemophilus Infections / drug therapy*
  • Haemophilus influenzae / drug effects
  • Haemophilus influenzae / genetics*
  • Humans
  • Levofloxacin*
  • Molecular Sequence Data
  • Ofloxacin / therapeutic use*
  • Pneumonia / drug therapy*
  • Pneumonia / microbiology
  • Treatment Failure

Substances

  • Anti-Infective Agents
  • Levofloxacin
  • Ofloxacin
  • DNA Gyrase

Associated data

  • GENBANK/AJ508043
  • GENBANK/AJ508044
  • GENBANK/AJ508045
  • GENBANK/AJ508046