Vitamin D Intake and Incidence of Multiple Sclerosis

Neurology. 2004 Jan 13;62(1):60-5. doi: 10.1212/01.wnl.0000101723.79681.38.

Abstract

Background: A protective effect of vitamin D on risk of multiple sclerosis (MS) has been proposed, but no prospective studies have addressed this hypothesis.

Methods: Dietary vitamin D intake was examined directly in relation to risk of MS in two large cohorts of women: the Nurses' Health Study (NHS; 92,253 women followed from 1980 to 2000) and Nurses' Health Study II (NHS II; 95,310 women followed from 1991 to 2001). Diet was assessed at baseline and updated every 4 years thereafter. During the follow-up, 173 cases of MS with onset of symptoms after baseline were confirmed.

Results: The pooled age-adjusted relative risk (RR) comparing women in the highest quintile of total vitamin D intake at baseline with those in the lowest was 0.67 (95% CI = 0.40 to 1.12; p for trend = 0.03). Intake of vitamin D from supplements was also inversely associated with risk of MS; the RR comparing women with intake of >or=400 IU/day with women with no supplemental vitamin D intake was 0.59 (95% CI = 0.38 to 0.91; p for trend = 0.006). No association was found between vitamin D from food and MS incidence.

Conclusion: These results support a protective effect of vitamin D intake on risk of developing MS.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Diet
  • Dietary Supplements
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Middle Aged
  • Multiple Sclerosis / epidemiology*
  • Multiple Sclerosis / prevention & control*
  • Nurses / statistics & numerical data
  • Odds Ratio
  • Prospective Studies
  • Risk
  • United States / epidemiology
  • Vitamin D / administration & dosage
  • Vitamin D / pharmacology*

Substances

  • Vitamin D