Alpha-synuclein haplotypes implicated in risk of Parkinson's disease

Neurology. 2004 Jan 13;62(1):128-31. doi: 10.1212/01.wnl.0000101721.25345.dc.

Abstract

The authors examined four- and six-loci haplotype constructs (from five single nucleotide polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with Parkinson's disease (PD) and controls in an ethnic Chinese population. Logistic regression analysis demonstrated an association of NACP-Rep1 (p = 0.002) and L478 (p < 0.0001) with risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific four-loci and six-loci haplotypes were significantly associated with an increased or decreased risk of PD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • China / ethnology
  • Female
  • Genetic Predisposition to Disease*
  • Haplotypes*
  • Humans
  • Incidence
  • Male
  • Microsatellite Repeats / genetics
  • Middle Aged
  • Monte Carlo Method
  • Nerve Tissue Proteins / genetics*
  • Odds Ratio
  • Parkinson Disease / epidemiology
  • Parkinson Disease / genetics*
  • Polymorphism, Genetic / genetics*
  • Risk Assessment
  • Singapore / epidemiology
  • Synucleins
  • alpha-Synuclein

Substances

  • Nerve Tissue Proteins
  • SNCA protein, human
  • Synucleins
  • alpha-Synuclein