Antigliadin antibodies in Huntington's disease

Neurology. 2004 Jan 13;62(1):132-3. doi: 10.1212/wnl.62.1.132.


The relevance of gluten sensitivity in sporadic and hereditary ataxia pathogenesis is unclear. The authors found high antigliadin antibody titers in 23 of 52 (44%) patients with Huntington's disease (HD), suggesting a previously unrecognized association between HD and gluten sensitivity. The results further question "gluten ataxia" as a distinct disease entity and raise the possibility that antigliadin antibodies in ataxia and other neurodegenerative diseases may be an epiphenomenon, the mechanisms of which remain to be investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / blood*
  • Female
  • Gliadin / immunology*
  • Humans
  • Huntington Disease / blood
  • Huntington Disease / genetics
  • Huntington Disease / immunology*
  • Immunoglobulin A / blood*
  • Immunoglobulin G / blood*
  • Male
  • Middle Aged
  • Trinucleotide Repeat Expansion


  • Antibodies
  • Immunoglobulin A
  • Immunoglobulin G
  • Gliadin