Treatment of lymphangioleiomyomatosis by ovariectomy, interferon alpha 2b and tamoxifen--a case report

Arch Gynecol Obstet. 1992;252(2):99-102. doi: 10.1007/BF02389635.


The gender-specific prevalence of lymphangioleiomyomatosis (LAM) in premenopausal women suggests a hormonal etiology. Despite the antiestrogenic treatment (ovariectomy, tamoxifen) this disease is often refractory to therapy and almost inevitably leads to the patient's death. We describe a case where the antiproliferative effect of systemically applied interferon alpha 2b was successfully employed in addition to ovariectomy and the patient reached complete remission.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chylothorax / therapy
  • Combined Modality Therapy
  • Female
  • Humans
  • Hysterectomy
  • Interferon alpha-2
  • Interferon-alpha / administration & dosage*
  • Lymphangiomyoma / therapy*
  • Mediastinal Neoplasms / therapy*
  • Ovariectomy*
  • Pelvic Neoplasms / therapy*
  • Recombinant Proteins
  • Retroperitoneal Neoplasms / therapy*
  • Tamoxifen / administration & dosage*


  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Tamoxifen