Tamoxifen treatment for pubertal gynecomastia

Int J Adolesc Med Health. 2003 Oct-Dec;15(4):359-63. doi: 10.1515/ijamh.2003.15.4.359.


We evaluated the efficacy of the tamoxifen treatment in 37 patients with pubertal gynecomastia. All had distinct, easily palpable breast swellings with a diameter of over three cm. Pain, tenderness, and swelling associated with gynecomastia were reported by six patients. Eight of the patients were obese. One patient also suffered from varicocele. Pain and size reduction was seen in all patients with tamoxifen treatment. No long-term side effects of tamoxifen were observed. The dose of tamoxifen was increased in three patients due to poor response. Two of the treatment group had recurrence problem at follow-up. We did not need to refer any patient to surgery. Tamoxifen treatment is relatively non-toxic, may be beneficial and we think it should be considered for pubertal gynecomastia.

MeSH terms

  • Adolescent
  • Child
  • Estrogen Antagonists / therapeutic use*
  • Gynecomastia / blood
  • Gynecomastia / complications
  • Gynecomastia / drug therapy*
  • Gynecomastia / physiopathology
  • Humans
  • Liver Function Tests
  • Male
  • Pain / etiology
  • Puberty / drug effects
  • Puberty / physiology
  • Tamoxifen / therapeutic use*
  • Testosterone / blood
  • Treatment Outcome
  • Turkey


  • Estrogen Antagonists
  • Tamoxifen
  • Testosterone