Sudden death in growth hormone-treated children with Prader-Willi syndrome

J Pediatr. 2004 Jan;144(1):129-31. doi: 10.1016/j.jpeds.2003.09.049.


A 4-year-old boy with Prader-Willi syndrome died suddenly while asleep on day 67 of growth hormone treatment. During treatment, snoring had worsened. Autopsy showed multifocal bronchopneumonia. This case and two others recently published suggest that growth hormone may be associated with obstructive apnea, respiratory infection, and sudden death in this condition.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Bronchopneumonia / chemically induced*
  • Child, Preschool
  • Contraindications
  • Death, Sudden / etiology*
  • Fatal Outcome
  • Human Growth Hormone / adverse effects*
  • Human Growth Hormone / therapeutic use
  • Humans
  • Male
  • Prader-Willi Syndrome / drug therapy*


  • Human Growth Hormone