Ulcers and gastritis

Endoscopy. 2004 Jan;36(1):42-7. doi: 10.1055/s-2004-814115.


Significant advances continue to be made in the area of gastritis and ulcer disease. Studies to identify the most appropriate use of capsule endoscopy have now confirmed that it is superior to other methods for identifying small-bowel mucosal pathology and sites of obscure gastrointestinal bleeding. It has increasingly been recognized that the complications of ulcer disease are secondary to the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and to interactions between NSAIDs and Helicobacter pylori. Effective prophylaxis for NSAID ulcers in H. pylori-negative individuals continues to be a challenge, as it has become clear that conclusions from studies focusing on "endoscopic ulcers" in patients whose H. pylori status was unknown provided a false sense of security. The concept of multifocal atrophic gastritis has been challenged. The precursor lesion to gastric cancer now appears to be a sheet of pseudopyloric metaplasia advancing into the gastric body with islands of intestinal metaplasia embedded within it. Multifactorial models such as those proposed for understanding periodontal disease, including the organism, environmental factors, and host factors, appear particularly applicable to understanding the pathogenesis of H. pylori-associated gastric cancer.

Publication types

  • Review

MeSH terms

  • Endoscopy, Gastrointestinal
  • Gastritis / diagnosis*
  • Gastritis / etiology
  • Gastritis / pathology
  • Gastrointestinal Hemorrhage / etiology
  • Helicobacter Infections / diagnosis
  • Helicobacter pylori / isolation & purification*
  • Humans
  • Peptic Ulcer / complications
  • Peptic Ulcer / diagnosis*
  • Peptic Ulcer / therapy
  • Proton Pump Inhibitors
  • Proton Pumps / adverse effects
  • Stomach Neoplasms / diagnosis


  • Proton Pump Inhibitors
  • Proton Pumps