Unsuccessful Treatment With Voriconazole of a Brain Abscess Due to Cladophialophora Bantiana

Scand J Infect Dis. 2003;35(11-12):892-3. doi: 10.1080/00365540310016736.

Abstract

Cladophialophora bantiana is a dematiaceous fungus, associated with brain abscess in normal or immunosuppressed patients. We report a case of CNS infection in this agent unsuccessfully treated by surgery and various antifungal compounds including high doses of voriconazole (6 mg/kg bid). No adverse effects related to this compound were observed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antifungal Agents / administration & dosage
  • Brain Abscess / diagnosis
  • Brain Abscess / drug therapy*
  • Brain Abscess / surgery
  • Central Nervous System Fungal Infections / diagnosis
  • Central Nervous System Fungal Infections / drug therapy*
  • Central Nervous System Fungal Infections / surgery
  • Cladosporium / classification
  • Cladosporium / drug effects*
  • Combined Modality Therapy
  • Disease Progression
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Fatal Outcome
  • Fungemia / diagnosis
  • Fungemia / drug therapy*
  • Humans
  • Male
  • Pyrimidines / administration & dosage*
  • Risk Assessment
  • Severity of Illness Index
  • Tomography, X-Ray Computed
  • Treatment Failure
  • Triazoles / administration & dosage*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole