[Experimental study of the effect of Astragalus membranaceus against herpes simplex virus type 1]

Di Yi Jun Yi Da Xue Xue Bao. 2004 Jan;24(1):57-8.
[Article in Chinese]

Abstract

Objective: To study the inhibitory effects of Astragalus membranaceus on herpes simplex virus type 1(HSV-1).

Methods: In the 2BS cells infected with HSV-1, the antiviral effect of Astragalus membranaceus decoction was investigated by observing the inhibition of HSV-1-induced cytopathic effect in response to treatment with the decoction.

Results: The half inhibition concentration (IC50) and minimal inhibition concentration (MIC) of Astragalus membranaceus were 0.98 and 1.95 g/ml respectively, with the therapeutic index (TI) of 128.

Conclusion: Astragalus membranaceus has obvious HSV-1-inhibiting efficacy and low cytotoxicity.

Publication types

  • English Abstract

MeSH terms

  • Antiviral Agents / pharmacology*
  • Astragalus Plant*
  • Herpesvirus 1, Human / drug effects*
  • Plant Extracts / pharmacology*

Substances

  • Antiviral Agents
  • Plant Extracts