Closure of bronchopleural fistulas using albumin-glutaraldehyde tissue adhesive

Ann Thorac Surg. 2004 Jan;77(1):326-8. doi: 10.1016/s0003-4975(03)00750-1.


Bronchopleural fistulas are a life-threatening complication of pulmonary resection. A 21-year-old woman developed a large bronchopleural fistula after undergoing a pneumonectomy for carcinoid tumor. Despite bronchial stump revision and omental coverage, the fistula recurred. The second patient is a 42-year-old woman with a history of multiple thoracotomies who developed a bronchopleural fistula following aortic root replacement. Using either rigid bronchoscopy or thoracoscopy, these fistulas were evaluated and sealed with an albumin-glutaraldehyde tissue adhesive that may have improved strength and biocompatibility compared with other tissue sealants. This approach may be an effective alternative in the treatment of bronchopleural fistulas.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Albumins*
  • Bronchial Fistula / therapy*
  • Female
  • Glutaral*
  • Humans
  • Pleural Diseases / therapy*
  • Respiratory Tract Fistula / therapy*
  • Tissue Adhesives*


  • Albumins
  • Tissue Adhesives
  • Glutaral