Abstract
Ambulatory electroencephalogram monitoring was performed for 18 HIV-infected subjects treated with efavirenz with and without insomnia and for 13 healthy control subjects. All patients receiving efavirenz had longer sleep latencies and shorter duration of deep sleep, although poor sleepers also showed reduced sleep efficiency and shorter duration of rapid eye movement sleep. Efavirenz plasma levels were higher in patients with insomnia and/or reduced sleep efficiency.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Alkynes
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Benzoxazines
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Cyclopropanes
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Electroencephalography
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Female
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HIV Infections / drug therapy
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Humans
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Male
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Oxazines / adverse effects*
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Oxazines / therapeutic use
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Reverse Transcriptase Inhibitors / adverse effects*
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Reverse Transcriptase Inhibitors / therapeutic use
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Sleep Initiation and Maintenance Disorders / chemically induced*
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Sleep Stages / drug effects*
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Sleep Wake Disorders / chemically induced
Substances
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Alkynes
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Benzoxazines
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Cyclopropanes
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Oxazines
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Reverse Transcriptase Inhibitors
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efavirenz