Cytolytic vaginosis (CV) infection is a little recognized but common cause of cyclic vulvovaginal complaints in women of reproductive age. Often misdiagnosed as candidiasis, most women have tried myriad antifungal medications to little or no avail. The history and physical examination is often similar to that seen in women with vaginal candidiasis. However in CV infection there is a luteal phase pattern of symptom recurrence. An astute clinician can make this diagnosis on vaginal microscopic examination and by meticulously ruling out other infections. Management consists of discontinuing all antifungal agents, using pads instead of tampons with menses, and taking baking soda sitz baths. Baking soda douches may also be helpful. As clinicians become familiar with CV infection, more women will be diagnosed and managed appropriately, leading to a long awaited resolution of their chronic vaginal complaints.